The Project

Methodological limitations may affect oncology and haematology trials, raising concerns about the applicability of their results.
We propose creating a novel framework with the scope of assessing individual trials leading
to marketing authorization in the field of oncology and haematology.
Methods include a pre-registered protocol, developing a list of features to be included within the framework
and a questionnaire sent to highly cited trialists.
Key principles in conducting the project are clinician, patient and public involvement,
transparency and open-science principles.

The project publication is available here.
Reviews of trials being assessed by the novel framework will be made publicly available online.
The THEOREMM project will be conducted following principles of open-science.
The research protocol is preregistered on the Open Science Framework (OSF) (available at https://osf.io/q3upe/),
the data generated during the project will be openly available through website repository,
and all peer-review publications will be open-access.